Genomics in Sudden Cardiac Death

Genomics in sudden cardiac death.

Sudden cardiac death (SCD) remains a public health problem of major magnitude. Contrary to earlier expectations, and despite decreased overall cardiac mortality, SCD rates appear to be rising in concert with escalating global prevalence of coronary disease and heart failure, the two major conditions predisposing to SCD. With the exception of the implantable defibrillator, there are few effectiv...

Cardiovascular disease and sudden cardiac death: between genetics and genomics.

In 1980, polymorphic variance in the human genomewasused to generate a first, physical map allowing monogenic traits to be traced to certain chromosomal regions. Due to the recognition of fragment length polymorphisms (microsatellite markers) with several different alleles at the same chromosomal locus, single nucleotide polymorphisms (SNP) became neglected in this instance for a long time. The...

Sudden Cardiac Death Sudden Cardiac Death in the Athlete

Sudden cardiac death (SCD) in a young athlete commonly brings to the forefront the many gaps in knowledge regarding how to predict and prevent these rare tragic events.1–3 Although the number of athletic sudden deaths is relatively small, with 100 to 150 competitive deaths during sports in the United States annually, they represent an important and emotionally charged public health issue, perha...

sudden cardiac death in young athletes

Sudden Cardiac Death Epidemiology and Genetics of Sudden Cardiac Death

From the Section of Electrophysiology, Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA (R.D.); Division of Preventive Medicine and Cardiovascular Medicine, Center for Arrhythmia Prevention, Brigham and Women’s Hospital, Boston, MA (C.M.A.). Correspondence to Christine M. Albert, MD, MPH, Division of Preventive Medicine and Cardiovascular Medicine, Center for Ar...